Experimental Strategies of Mesenchymal Stem Cell Propagation: Adverse Events and Potential Risk of Functional Changes
Mesenchymal stem cells (MSCs) are attractive candidates for cell-based tissue repair approaches.Hundreds of clinical trials using MSCs have been completed and many others are still being investigated.For most therapeutic applications, MSC propagation in vitro is often required.However, ex vivo culture condition is not fully physiological and may af